Trimebutine 100mg (100 tablets)

Trimebutine is a medication used to help regulate gastrointestinal motility and treat functional gastrointestinal disorders like irritable bowel syndrome (IBS). Here are some key details about trimebutine:

• It is categorized as an “intestinal motility agent” or prokinetic agent. It helps normalize motility in both hypermotile and hypomotile GI conditions.
• Trimebutine works primarily as a peripheral mu-opioid receptor agonist, binding to opioid receptors in the gut. This helps reduce intestinal pain signaling and regulate motility.
• It is available in oral formulations (tablets) and is taken before meals usually 3 times per day.
• Trimebutine is used for various GI issues like IBS, gastric ulcers, abdominal pain, and post-operative ileus. It can help relieve abdominal pain and normalize bowel function.
• Common side effects may include mild nausea, vomiting, constipation or diarrhea. It is generally well tolerated.
• Trimebutine was originally developed in France and is widely used in Europe for IBS and other GI disorders. It is not FDA approved for use in the United States.
• Dosage adjustments are needed for patients with renal impairment due to the risk of accumulation. Caution is advised if combining with other prokinetics.